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KMID : 1161520210250060396
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Animal Cells and Systems
2021 Volume.25 No. 6 p.396 ~ p.404
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Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
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Jang Mi-Gyeong
Oh Jung-Min
Ko Hee-Chul
Kim Jae-Won
Baek Song-Yee
Jin Yeong-Jun
Hur Sung-Pyo
Kim Se-Jae
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Abstract
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Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet. Sprague?Dawley rats were fed with a 46% carbohydrate diet (HC group), 60% high-fructose diet (HF group), or HF diet supplemented with CT (500?mg/kg of body weight/day, CT group) via drinking water for 16 weeks. Results showed that CT alleviated HF diet-induced insulin resistance, dyslipidemia, and hepatic steatosis In liver tissues, CT affected the signaling pathways of AMP-activated protein kinase, peroxisome proliferator-activated receptor α (PPARα), and sterol regulatory element binding protein 1. CT enriched the genes that were mainly involved in cytokine-cytokine receptor interaction, PPAR, PI3K-Akt signaling pathways, and fatty acid metabolism pathway. These results suggest that CT is a promising therapeutic against metabolic disorders.
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KEYWORD
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Clerodendrum trichotomum, dyslipidemia, insulin resistance, high fructose diet, metabolic disorders
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